Senior Scientist I – siRNA, Pipeline Development
AbbVie
Senior Scientist I – siRNA, Pipeline Development
Job Description
At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.Position Overview:AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department in Cambridge, MA. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.Responsibilities:Lead research efforts within a cross-functional team to advance new extrahepatic therapeutic targets for siRNA -based drug discovery.Design and execute in vitro and in vivo proof-of-concept studies to assess target engagement, validate biological pathways and therapeutic benefits.Develop and optimize assays and tools to evaluate siRNA library for their delivery, efficacy, and off-target risks.Contribute scientific leadership and expertise in target biology, target selection and pipeline development.Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.Mentor and support junior scientists within the team.
Locations
- Cambridge, MA
Salary
94,000 - 178,500 USD / yearly
Estimated Salary Rangemedium confidence
120,000 - 160,000 USD / yearly
Source: AI estimated from job description
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- siRNA design and oligonucleotide therapeuticsintermediate
- In vitro and in vivo assay developmentintermediate
- Target validation and biological pathway analysisintermediate
- Data analysis and interpretationintermediate
- Scientific communication and collaborationintermediate
- Laboratory productivity and rigorintermediate
Required Qualifications
- Advanced degree (PhD preferred) in molecular biology, biochemistry, or related field (experience)
- Extensive experience in RNA-based therapeutics, particularly siRNA (experience)
- Proven track record in designing and executing in vitro and in vivo studies (experience)
- Strong background in target biology and oligonucleotide therapeutics (experience)
- Demonstrated ability to lead cross-functional teams and mentor junior scientists (experience)
Responsibilities
- Lead research efforts within a cross-functional team to advance new extrahepatic therapeutic targets for siRNA-based drug discovery
- Design and execute in vitro and in vivo proof-of-concept studies to assess target engagement, validate biological pathways and therapeutic benefits
- Develop and optimize assays and tools to evaluate siRNA library for their delivery, efficacy, and off-target risks
- Contribute scientific leadership and expertise in target biology, target selection and pipeline development
- Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions
- Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization
- Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications
- Mentor and support junior scientists within the team
Benefits
- general: Opportunity to work on innovative RNA-based therapies revolutionizing patient care
- general: Collaborative environment in a leading biopharmaceutical company
- general: Professional development through scientific leadership and publication opportunities
- general: Supportive team structure with cross-functional collaboration
Tags & Categories
Senior Scientist I – siRNA, Pipeline Development
AbbVie
Senior Scientist I – siRNA, Pipeline Development
Job Description
At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.Position Overview:AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department in Cambridge, MA. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.Responsibilities:Lead research efforts within a cross-functional team to advance new extrahepatic therapeutic targets for siRNA -based drug discovery.Design and execute in vitro and in vivo proof-of-concept studies to assess target engagement, validate biological pathways and therapeutic benefits.Develop and optimize assays and tools to evaluate siRNA library for their delivery, efficacy, and off-target risks.Contribute scientific leadership and expertise in target biology, target selection and pipeline development.Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.Mentor and support junior scientists within the team.
Locations
- Cambridge, MA
Salary
94,000 - 178,500 USD / yearly
Estimated Salary Rangemedium confidence
120,000 - 160,000 USD / yearly
Source: AI estimated from job description
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- siRNA design and oligonucleotide therapeuticsintermediate
- In vitro and in vivo assay developmentintermediate
- Target validation and biological pathway analysisintermediate
- Data analysis and interpretationintermediate
- Scientific communication and collaborationintermediate
- Laboratory productivity and rigorintermediate
Required Qualifications
- Advanced degree (PhD preferred) in molecular biology, biochemistry, or related field (experience)
- Extensive experience in RNA-based therapeutics, particularly siRNA (experience)
- Proven track record in designing and executing in vitro and in vivo studies (experience)
- Strong background in target biology and oligonucleotide therapeutics (experience)
- Demonstrated ability to lead cross-functional teams and mentor junior scientists (experience)
Responsibilities
- Lead research efforts within a cross-functional team to advance new extrahepatic therapeutic targets for siRNA-based drug discovery
- Design and execute in vitro and in vivo proof-of-concept studies to assess target engagement, validate biological pathways and therapeutic benefits
- Develop and optimize assays and tools to evaluate siRNA library for their delivery, efficacy, and off-target risks
- Contribute scientific leadership and expertise in target biology, target selection and pipeline development
- Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions
- Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization
- Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications
- Mentor and support junior scientists within the team
Benefits
- general: Opportunity to work on innovative RNA-based therapies revolutionizing patient care
- general: Collaborative environment in a leading biopharmaceutical company
- general: Professional development through scientific leadership and publication opportunities
- general: Supportive team structure with cross-functional collaboration
Tags & Categories