Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated and experienced scientist to join the Protein Sciences Analytical Team in Worcester, MA. This position provides a unique opportunity to directly impact multiple Discovery Research Therapeutic Areas (TAs) and projects by delivering in-depth analytical and functional characterization of biologics and biopharmaceutical products—including complex protein antigens, monoclonal antibodies, multi-specifics, and other antibody-like biologics. The ideal candidate will have a strong background in protein analytical characterization, with expertise in structural mass spectrometry, including hydrogen-deuterium exchange mass spectrometry (HDX-MS), crosslinking mass spectrometry (XL-MS), and covalent labeling mass spectrometry (CL-MS) to characterize epitopes and antigen-antibody interactions. The successful candidate will foster productive collaborations across functional groups and therapeutic areas. This is an excellent opportunity for a motivated scientist to make a significant impact in a collaborative and innovative environment. Join us in bringing innovative medicines to patients!Key Responsibilities:Independently develop and execute high-throughput HDX-MS workflows for epitope mapping analysis of biotherapeutics to support discovery pipeline projects.Develop, optimize, validate, and apply innovative structural MS methods (including XL-MS and CL-MS) to characterize epitopes and antigen-antibody interactions.Demonstrate scientific initiative and creativity by establishing novel workflows and strategies for the characterization and screening of biologics—including non-traditional modalities such as multi-specifics, alternative scaffolds, and fusion proteins—to support BGM and TA projects.Collaborate with external partners, CROs, or vendors to advance project objectives.Analyze, document, and report data concisely; formulate conclusions and design follow-on experiments based on multidisciplinary inputs.Resolve key project challenges by leveraging analytical tools, information, and technical expertise.Communicate project progress, data analyses, and technical recommendations clearly and promptly to cross-functional teams and senior management.Present original research and findings internally and at external scientific conferences; contribute to scientific papers, patents, and technical reports as an author or co-author.