Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology
Bristol-Myers Squibb
Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology
Job Description
In the role as Principal Scientist within Oncology Discovery Pharmacology and In vivo Biology, the ideal candidate will: Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects. Demonstrate critical thinking to address project challenges and independently drive the program forward with solution-oriented mindset. Characterize drug candidates in vivo as part of the lead selection process, utilizing strong foundational knowledge of building PK, PD, BioD and efficacy relationship in vivo and employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND. Identify and develop state of the art in vivo models, experimental protocols and relevant assays. Work with cross-functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings. Design, independently execute and deliver experiments with comprehensive high quality data sets to drive decision making. Interpret results of complex experiments. Use relevant information, technology and resources, contributing to complex team problem resolution and goals. Proactively foster relationships across disciplines to facilitate decision making process. Participates in the decision-making process for completion of team goals and communicates program strategy and timelines to Project teams. Prepare and present comprehensive technical or project updates in team meetings and other forums. Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy. Encourages use of experimental / innovative approaches within group. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Supporting People with Disabilities Bachelor's Degree 8+ years of academic and / or industry experience PhD immunology, cancer biology or relevant biological science with 4+ years of relevant industry experience in in vivo pharmacology and a comprehensive expertise in oncology drug discovery, T cell biology and immuno-oncology. Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic. Demonstrated ability to independently develop focused in vivo strategies and utilizing PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers is required. Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research is required. Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development is highly desired. Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex and immune profiling by flow cytometry. Proficient in developing FACS panels, executing ex-vivo profiling approaches and analyzing FACS datasets. Familiar with PET/CT, IVIS and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities. Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues are required. Competitive candidates are expected to have a strong track record of independent and innovative research.
About the Role/Company
- The role is within Oncology Discovery Pharmacology and In vivo Biology
Key Responsibilities
- Function as Pharmacology lead and provide support for T cell engager drug discovery programs
- Lead the development of in vivo strategies from target concept to Proof of Concept in patients
- Apply scientific and technical skills and functional knowledge to complex projects
- Demonstrate critical thinking to address project challenges and independently drive the program forward with a solution-oriented mindset
- Characterize drug candidates in vivo as part of the lead selection process
- Utilize strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivo
- Employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND
- Identify and develop state-of-the-art in vivo models, experimental protocols, and relevant assays
- Work with cross-functional teams to participate in development and implementation of program strategy
- Integrate in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings
- Design, independently execute, and deliver experiments with comprehensive high-quality data sets to drive decision making
- Interpret results of complex experiments
- Use relevant information, technology, and resources, contributing to complex team problem resolution and goals
- Proactively foster relationships across disciplines to facilitate the decision-making process
- Participate in the decision-making process for completion of team goals
- Communicate program strategy and timelines to Project teams
- Prepare and present comprehensive technical or project updates in team meetings and other forums
- Lead initiatives related to development of new approaches/technologies within T-Cell engager strategy
- Encourage use of experimental/innovative approaches within the group
Required Qualifications
- Bachelor's Degree
- PhD in immunology, cancer biology, or relevant biological science
- + years of academic and/or industry experience
- + years of relevant industry experience in in vivo pharmacology
- Comprehensive expertise in oncology drug discovery, T cell biology, and immuno-oncology
- Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic
- Demonstrated ability to independently develop focused in vivo strategies and utilize PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers
- Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research
Preferred Qualifications
- Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development
- Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex, and immune profiling by flow cytometry
- Proficient in developing FACS panels, executing ex-vivo profiling approaches, and analyzing FACS datasets
- Familiar with PET/CT, IVIS, and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities
Skills Required
- Strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivo
- Ability to employ innovative approaches and novel technologies
- Excellent interpersonal and communication skills
- Ability to interact effectively with internal and external colleagues
- Strong track record of independent and innovative research
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
- Supporting People with Disabilities
Locations
- Cambridge Crossing MA, United States
Salary
Salary not disclosed
Estimated Salary Rangemedium confidence
180,000 - 250,000 USD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivointermediate
- Ability to employ innovative approaches and novel technologiesintermediate
- Excellent interpersonal and communication skillsintermediate
- Ability to interact effectively with internal and external colleaguesintermediate
- Strong track record of independent and innovative researchintermediate
Required Qualifications
- Bachelor's Degree (experience)
- PhD in immunology, cancer biology, or relevant biological science (experience)
- + years of academic and/or industry experience (experience)
- + years of relevant industry experience in in vivo pharmacology (experience)
- Comprehensive expertise in oncology drug discovery, T cell biology, and immuno-oncology (experience)
- Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic (experience)
- Demonstrated ability to independently develop focused in vivo strategies and utilize PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers (experience)
- Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research (experience)
Preferred Qualifications
- Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development (experience)
- Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex, and immune profiling by flow cytometry (experience)
- Proficient in developing FACS panels, executing ex-vivo profiling approaches, and analyzing FACS datasets (experience)
- Familiar with PET/CT, IVIS, and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities (experience)
Responsibilities
- Function as Pharmacology lead and provide support for T cell engager drug discovery programs
- Lead the development of in vivo strategies from target concept to Proof of Concept in patients
- Apply scientific and technical skills and functional knowledge to complex projects
- Demonstrate critical thinking to address project challenges and independently drive the program forward with a solution-oriented mindset
- Characterize drug candidates in vivo as part of the lead selection process
- Utilize strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivo
- Employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND
- Identify and develop state-of-the-art in vivo models, experimental protocols, and relevant assays
- Work with cross-functional teams to participate in development and implementation of program strategy
- Integrate in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings
- Design, independently execute, and deliver experiments with comprehensive high-quality data sets to drive decision making
- Interpret results of complex experiments
- Use relevant information, technology, and resources, contributing to complex team problem resolution and goals
- Proactively foster relationships across disciplines to facilitate the decision-making process
- Participate in the decision-making process for completion of team goals
- Communicate program strategy and timelines to Project teams
- Prepare and present comprehensive technical or project updates in team meetings and other forums
- Lead initiatives related to development of new approaches/technologies within T-Cell engager strategy
- Encourage use of experimental/innovative approaches within the group
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
- general: Supporting People with Disabilities
Tags & Categories
Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology
Bristol-Myers Squibb
Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology
Job Description
In the role as Principal Scientist within Oncology Discovery Pharmacology and In vivo Biology, the ideal candidate will: Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects. Demonstrate critical thinking to address project challenges and independently drive the program forward with solution-oriented mindset. Characterize drug candidates in vivo as part of the lead selection process, utilizing strong foundational knowledge of building PK, PD, BioD and efficacy relationship in vivo and employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND. Identify and develop state of the art in vivo models, experimental protocols and relevant assays. Work with cross-functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings. Design, independently execute and deliver experiments with comprehensive high quality data sets to drive decision making. Interpret results of complex experiments. Use relevant information, technology and resources, contributing to complex team problem resolution and goals. Proactively foster relationships across disciplines to facilitate decision making process. Participates in the decision-making process for completion of team goals and communicates program strategy and timelines to Project teams. Prepare and present comprehensive technical or project updates in team meetings and other forums. Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy. Encourages use of experimental / innovative approaches within group. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Supporting People with Disabilities Bachelor's Degree 8+ years of academic and / or industry experience PhD immunology, cancer biology or relevant biological science with 4+ years of relevant industry experience in in vivo pharmacology and a comprehensive expertise in oncology drug discovery, T cell biology and immuno-oncology. Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic. Demonstrated ability to independently develop focused in vivo strategies and utilizing PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers is required. Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research is required. Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development is highly desired. Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex and immune profiling by flow cytometry. Proficient in developing FACS panels, executing ex-vivo profiling approaches and analyzing FACS datasets. Familiar with PET/CT, IVIS and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities. Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues are required. Competitive candidates are expected to have a strong track record of independent and innovative research.
About the Role/Company
- The role is within Oncology Discovery Pharmacology and In vivo Biology
Key Responsibilities
- Function as Pharmacology lead and provide support for T cell engager drug discovery programs
- Lead the development of in vivo strategies from target concept to Proof of Concept in patients
- Apply scientific and technical skills and functional knowledge to complex projects
- Demonstrate critical thinking to address project challenges and independently drive the program forward with a solution-oriented mindset
- Characterize drug candidates in vivo as part of the lead selection process
- Utilize strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivo
- Employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND
- Identify and develop state-of-the-art in vivo models, experimental protocols, and relevant assays
- Work with cross-functional teams to participate in development and implementation of program strategy
- Integrate in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings
- Design, independently execute, and deliver experiments with comprehensive high-quality data sets to drive decision making
- Interpret results of complex experiments
- Use relevant information, technology, and resources, contributing to complex team problem resolution and goals
- Proactively foster relationships across disciplines to facilitate the decision-making process
- Participate in the decision-making process for completion of team goals
- Communicate program strategy and timelines to Project teams
- Prepare and present comprehensive technical or project updates in team meetings and other forums
- Lead initiatives related to development of new approaches/technologies within T-Cell engager strategy
- Encourage use of experimental/innovative approaches within the group
Required Qualifications
- Bachelor's Degree
- PhD in immunology, cancer biology, or relevant biological science
- + years of academic and/or industry experience
- + years of relevant industry experience in in vivo pharmacology
- Comprehensive expertise in oncology drug discovery, T cell biology, and immuno-oncology
- Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic
- Demonstrated ability to independently develop focused in vivo strategies and utilize PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers
- Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research
Preferred Qualifications
- Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development
- Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex, and immune profiling by flow cytometry
- Proficient in developing FACS panels, executing ex-vivo profiling approaches, and analyzing FACS datasets
- Familiar with PET/CT, IVIS, and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities
Skills Required
- Strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivo
- Ability to employ innovative approaches and novel technologies
- Excellent interpersonal and communication skills
- Ability to interact effectively with internal and external colleagues
- Strong track record of independent and innovative research
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
- Supporting People with Disabilities
Locations
- Cambridge Crossing MA, United States
Salary
Salary not disclosed
Estimated Salary Rangemedium confidence
180,000 - 250,000 USD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivointermediate
- Ability to employ innovative approaches and novel technologiesintermediate
- Excellent interpersonal and communication skillsintermediate
- Ability to interact effectively with internal and external colleaguesintermediate
- Strong track record of independent and innovative researchintermediate
Required Qualifications
- Bachelor's Degree (experience)
- PhD in immunology, cancer biology, or relevant biological science (experience)
- + years of academic and/or industry experience (experience)
- + years of relevant industry experience in in vivo pharmacology (experience)
- Comprehensive expertise in oncology drug discovery, T cell biology, and immuno-oncology (experience)
- Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers as cancer therapeutic (experience)
- Demonstrated ability to independently develop focused in vivo strategies and utilize PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers (experience)
- Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research (experience)
Preferred Qualifications
- Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development (experience)
- Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex, and immune profiling by flow cytometry (experience)
- Proficient in developing FACS panels, executing ex-vivo profiling approaches, and analyzing FACS datasets (experience)
- Familiar with PET/CT, IVIS, and other novel imaging approaches, data analysis methods for evaluating Biodistribution of biological modalities (experience)
Responsibilities
- Function as Pharmacology lead and provide support for T cell engager drug discovery programs
- Lead the development of in vivo strategies from target concept to Proof of Concept in patients
- Apply scientific and technical skills and functional knowledge to complex projects
- Demonstrate critical thinking to address project challenges and independently drive the program forward with a solution-oriented mindset
- Characterize drug candidates in vivo as part of the lead selection process
- Utilize strong foundational knowledge of building PK, PD, BioD, and efficacy relationships in vivo
- Employ innovative approaches and novel technologies to advance research molecules towards development candidate selection and IND
- Identify and develop state-of-the-art in vivo models, experimental protocols, and relevant assays
- Work with cross-functional teams to participate in development and implementation of program strategy
- Integrate in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings
- Design, independently execute, and deliver experiments with comprehensive high-quality data sets to drive decision making
- Interpret results of complex experiments
- Use relevant information, technology, and resources, contributing to complex team problem resolution and goals
- Proactively foster relationships across disciplines to facilitate the decision-making process
- Participate in the decision-making process for completion of team goals
- Communicate program strategy and timelines to Project teams
- Prepare and present comprehensive technical or project updates in team meetings and other forums
- Lead initiatives related to development of new approaches/technologies within T-Cell engager strategy
- Encourage use of experimental/innovative approaches within the group
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
- general: Supporting People with Disabilities
Tags & Categories