Principal Scientist, Non Viral Attribute Sciences
Bristol-Myers Squibb
Principal Scientist, Non Viral Attribute Sciences
Job Description
Hands on development of robust analytical methods to support internal process development of non-viral materials, and their use thereof in cells Provide technical and scientific subject matter expertise to drive early non-viral development strategies Assist in the assessment of the analytical readiness of CDMO/CRO's Identify and define Critical Quality Attributes (CQA) of non-viral drug substances Identify key measures of drug substance function in primary and immortal cells Contribute to the authorship of SOPs, technical reports and regulatory submission documents (including S.3.1 sections) Present and discuss findings to stakeholders and senior leadership Collaborate cross-functionally with CTAD peers, research, process development and CMC to support early platform assessment efforts Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline with demonstrated track/record of experience leading teams to achieve objectives in industrial and/or academic settings (5+ years for Ph.D) Profound understanding of RNA and RNP biology especially in cell therapy applications Experience characterizing function of RNA and RNP reagents in primary cells (primary cell culture, gene expression by flow or molecular readout, potency and other functional assays) Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping) Hands-on experience working with a non-viral gene delivery platform Experience with automation and high throughput analytical solutions is desired Motivation and drive to acquire new skills and knowledge Willingness to work in a regulated industrial environment Excellent verbal, written, and oral communication skills
Key Responsibilities
- Develop robust analytical methods to support internal process development of non-viral materials and their use in cells
- Provide technical and scientific subject matter expertise to drive early non-viral development strategies
- Assist in the assessment of the analytical readiness of CDMO/CRO's
- Identify and define Critical Quality Attributes (CQA) of non-viral drug substances
- Identify key measures of drug substance function in primary and immortal cells
- Contribute to the authorship of SOPs, technical reports, and regulatory submission documents (including S.3.1 sections)
- Present and discuss findings to stakeholders and senior leadership
- Collaborate cross-functionally with CTAD peers, research, process development, and CMC to support early platform assessment efforts
Required Qualifications
- Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline
- + years of experience leading teams to achieve objectives in industrial and/or academic settings
- Profound understanding of RNA and RNP biology especially in cell therapy applications
- Experience characterizing function of RNA and RNP reagents in primary cells
Preferred Qualifications
- Experience with automation and high throughput analytical solutions
- Motivation and drive to acquire new skills and knowledge
Skills Required
- Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping)
- Hands-on experience working with a non-viral gene delivery platform
- Excellent verbal, written, and oral communication skills
- Willingness to work in a regulated industrial environment
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
Locations
- Seattle 400 Dexter WA, United States
Salary
Estimated Salary Rangemedium confidence
150,000 - 250,000 USD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping)intermediate
- Hands-on experience working with a non-viral gene delivery platformintermediate
- Excellent verbal, written, and oral communication skillsintermediate
- Willingness to work in a regulated industrial environmentintermediate
Required Qualifications
- Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline (experience)
- + years of experience leading teams to achieve objectives in industrial and/or academic settings (experience)
- Profound understanding of RNA and RNP biology especially in cell therapy applications (experience)
- Experience characterizing function of RNA and RNP reagents in primary cells (experience)
Preferred Qualifications
- Experience with automation and high throughput analytical solutions (experience)
- Motivation and drive to acquire new skills and knowledge (experience)
Responsibilities
- Develop robust analytical methods to support internal process development of non-viral materials and their use in cells
- Provide technical and scientific subject matter expertise to drive early non-viral development strategies
- Assist in the assessment of the analytical readiness of CDMO/CRO's
- Identify and define Critical Quality Attributes (CQA) of non-viral drug substances
- Identify key measures of drug substance function in primary and immortal cells
- Contribute to the authorship of SOPs, technical reports, and regulatory submission documents (including S.3.1 sections)
- Present and discuss findings to stakeholders and senior leadership
- Collaborate cross-functionally with CTAD peers, research, process development, and CMC to support early platform assessment efforts
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
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Principal Scientist, Non Viral Attribute Sciences
Bristol-Myers Squibb
Principal Scientist, Non Viral Attribute Sciences
Job Description
Hands on development of robust analytical methods to support internal process development of non-viral materials, and their use thereof in cells Provide technical and scientific subject matter expertise to drive early non-viral development strategies Assist in the assessment of the analytical readiness of CDMO/CRO's Identify and define Critical Quality Attributes (CQA) of non-viral drug substances Identify key measures of drug substance function in primary and immortal cells Contribute to the authorship of SOPs, technical reports and regulatory submission documents (including S.3.1 sections) Present and discuss findings to stakeholders and senior leadership Collaborate cross-functionally with CTAD peers, research, process development and CMC to support early platform assessment efforts Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline with demonstrated track/record of experience leading teams to achieve objectives in industrial and/or academic settings (5+ years for Ph.D) Profound understanding of RNA and RNP biology especially in cell therapy applications Experience characterizing function of RNA and RNP reagents in primary cells (primary cell culture, gene expression by flow or molecular readout, potency and other functional assays) Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping) Hands-on experience working with a non-viral gene delivery platform Experience with automation and high throughput analytical solutions is desired Motivation and drive to acquire new skills and knowledge Willingness to work in a regulated industrial environment Excellent verbal, written, and oral communication skills
Key Responsibilities
- Develop robust analytical methods to support internal process development of non-viral materials and their use in cells
- Provide technical and scientific subject matter expertise to drive early non-viral development strategies
- Assist in the assessment of the analytical readiness of CDMO/CRO's
- Identify and define Critical Quality Attributes (CQA) of non-viral drug substances
- Identify key measures of drug substance function in primary and immortal cells
- Contribute to the authorship of SOPs, technical reports, and regulatory submission documents (including S.3.1 sections)
- Present and discuss findings to stakeholders and senior leadership
- Collaborate cross-functionally with CTAD peers, research, process development, and CMC to support early platform assessment efforts
Required Qualifications
- Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline
- + years of experience leading teams to achieve objectives in industrial and/or academic settings
- Profound understanding of RNA and RNP biology especially in cell therapy applications
- Experience characterizing function of RNA and RNP reagents in primary cells
Preferred Qualifications
- Experience with automation and high throughput analytical solutions
- Motivation and drive to acquire new skills and knowledge
Skills Required
- Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping)
- Hands-on experience working with a non-viral gene delivery platform
- Excellent verbal, written, and oral communication skills
- Willingness to work in a regulated industrial environment
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
Locations
- Seattle 400 Dexter WA, United States
Salary
Estimated Salary Rangemedium confidence
150,000 - 250,000 USD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Familiarity with analytical methods used to characterize non-viral drug substances (ion exchange chromatography, size exclusion chromatography, icIEF, FRET, protein and nucleic acid quantitation, peptide mapping)intermediate
- Hands-on experience working with a non-viral gene delivery platformintermediate
- Excellent verbal, written, and oral communication skillsintermediate
- Willingness to work in a regulated industrial environmentintermediate
Required Qualifications
- Ph.D. in Immunology, Cell/Molecular Biology, Analytical Chemistry, Biomedical Engineering or related discipline (experience)
- + years of experience leading teams to achieve objectives in industrial and/or academic settings (experience)
- Profound understanding of RNA and RNP biology especially in cell therapy applications (experience)
- Experience characterizing function of RNA and RNP reagents in primary cells (experience)
Preferred Qualifications
- Experience with automation and high throughput analytical solutions (experience)
- Motivation and drive to acquire new skills and knowledge (experience)
Responsibilities
- Develop robust analytical methods to support internal process development of non-viral materials and their use in cells
- Provide technical and scientific subject matter expertise to drive early non-viral development strategies
- Assist in the assessment of the analytical readiness of CDMO/CRO's
- Identify and define Critical Quality Attributes (CQA) of non-viral drug substances
- Identify key measures of drug substance function in primary and immortal cells
- Contribute to the authorship of SOPs, technical reports, and regulatory submission documents (including S.3.1 sections)
- Present and discuss findings to stakeholders and senior leadership
- Collaborate cross-functionally with CTAD peers, research, process development, and CMC to support early platform assessment efforts
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
Tags & Categories
Answer 10 quick questions to check your fit for Principal Scientist, Non Viral Attribute Sciences @ Bristol-Myers Squibb.
10 Questions
~2 Minutes
Instant Score
Related Books and Jobs