Senior Associate Scientist, Pharmacology
Bristol-Myers Squibb
Senior Associate Scientist, Pharmacology
Job Description
Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents. Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy. Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums. Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques. Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols. Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records. Collaborate effectively within the immediate team and cross-functionally to advance program objectives. Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis. May involve working outside standard business hours, including weekends, holidays, and early mornings, to support critical in vivo studies and project deadlines. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. B.Sc. with 4-5+ years of experience or M.Sc. with 2-3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline. Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings) is preferred. Prior experience working with radioactive materials is strongly preferred. Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal research. Ability to perform IV compound administration and SC engraftment is mandatory. Hands-on experience with cell-based assays, molecular biology techniques (ELISA, western blot, qPCR, immunohistochemistry), and related protocols. Working knowledge of MS 365 and GraphPad Prism. Strong work ethic, self-motivation, adaptability, and organizational skills. Ability to work in a fast-paced, dynamic, and collaborative environment. Excellent written, oral communication, and presentation skills. Experience with in vivo imaging modalities is a plus. Familiarity with the drug development process and interdisciplinary teamwork.
Key Responsibilities
- Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents
- Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy
- Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums
- Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques
- Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols
- Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records
- Collaborate effectively within the immediate team and cross-functionally to advance program objectives
- Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis
Required Qualifications
- B.Sc. with 4-5+ years of experience or M.Sc. with 2-3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline
Preferred Qualifications
- Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings)
- Prior experience working with radioactive materials
- Experience with in vivo imaging modalities
- Familiarity with the drug development process and interdisciplinary teamwork
Skills Required
- Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal research
- Ability to perform IV compound administration and SC engraftment
- Hands-on experience with cell-based assays, molecular biology techniques (ELISA, western blot, qPCR, immunohistochemistry), and related protocols
- Working knowledge of MS 365 and GraphPad Prism
- Strong work ethic, self-motivation, adaptability, and organizational skills
- Ability to work in a fast-paced, dynamic, and collaborative environment
- Excellent written, oral communication, and presentation skills
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
Additional Requirements
- May involve working outside standard business hours, including weekends, holidays, and early mornings, to support critical in vivo studies and project deadlines
Locations
- San Diego RayzeBio, Canada
Salary
Estimated Salary Rangemedium confidence
80,000 - 120,000 CAD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal researchintermediate
- Ability to perform IV compound administration and SC engraftmentintermediate
- Hands-on experience with cell-based assays, molecular biology techniques (ELISA, western blot, qPCR, immunohistochemistry), and related protocolsintermediate
- Working knowledge of MS 365 and GraphPad Prismintermediate
- Strong work ethic, self-motivation, adaptability, and organizational skillsintermediate
- Ability to work in a fast-paced, dynamic, and collaborative environmentintermediate
- Excellent written, oral communication, and presentation skillsintermediate
Required Qualifications
- B.Sc. with 4-5+ years of experience or M.Sc. with 2-3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline (experience)
Preferred Qualifications
- Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings) (experience)
- Prior experience working with radioactive materials (experience)
- Experience with in vivo imaging modalities (experience)
- Familiarity with the drug development process and interdisciplinary teamwork (experience)
Responsibilities
- Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents
- Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy
- Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums
- Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques
- Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols
- Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records
- Collaborate effectively within the immediate team and cross-functionally to advance program objectives
- Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
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Senior Associate Scientist, Pharmacology
Bristol-Myers Squibb
Senior Associate Scientist, Pharmacology
Job Description
Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents. Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy. Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums. Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques. Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols. Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records. Collaborate effectively within the immediate team and cross-functionally to advance program objectives. Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis. May involve working outside standard business hours, including weekends, holidays, and early mornings, to support critical in vivo studies and project deadlines. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. B.Sc. with 4-5+ years of experience or M.Sc. with 2-3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline. Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings) is preferred. Prior experience working with radioactive materials is strongly preferred. Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal research. Ability to perform IV compound administration and SC engraftment is mandatory. Hands-on experience with cell-based assays, molecular biology techniques (ELISA, western blot, qPCR, immunohistochemistry), and related protocols. Working knowledge of MS 365 and GraphPad Prism. Strong work ethic, self-motivation, adaptability, and organizational skills. Ability to work in a fast-paced, dynamic, and collaborative environment. Excellent written, oral communication, and presentation skills. Experience with in vivo imaging modalities is a plus. Familiarity with the drug development process and interdisciplinary teamwork.
Key Responsibilities
- Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents
- Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy
- Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums
- Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques
- Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols
- Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records
- Collaborate effectively within the immediate team and cross-functionally to advance program objectives
- Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis
Required Qualifications
- B.Sc. with 4-5+ years of experience or M.Sc. with 2-3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline
Preferred Qualifications
- Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings)
- Prior experience working with radioactive materials
- Experience with in vivo imaging modalities
- Familiarity with the drug development process and interdisciplinary teamwork
Skills Required
- Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal research
- Ability to perform IV compound administration and SC engraftment
- Hands-on experience with cell-based assays, molecular biology techniques (ELISA, western blot, qPCR, immunohistochemistry), and related protocols
- Working knowledge of MS 365 and GraphPad Prism
- Strong work ethic, self-motivation, adaptability, and organizational skills
- Ability to work in a fast-paced, dynamic, and collaborative environment
- Excellent written, oral communication, and presentation skills
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
Additional Requirements
- May involve working outside standard business hours, including weekends, holidays, and early mornings, to support critical in vivo studies and project deadlines
Locations
- San Diego RayzeBio, Canada
Salary
Estimated Salary Rangemedium confidence
80,000 - 120,000 CAD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Technical proficiency in rodent handling (immune-compromised and -competent mice), aseptic procedures, and lab animal researchintermediate
- Ability to perform IV compound administration and SC engraftmentintermediate
- Hands-on experience with cell-based assays, molecular biology techniques (ELISA, western blot, qPCR, immunohistochemistry), and related protocolsintermediate
- Working knowledge of MS 365 and GraphPad Prismintermediate
- Strong work ethic, self-motivation, adaptability, and organizational skillsintermediate
- Ability to work in a fast-paced, dynamic, and collaborative environmentintermediate
- Excellent written, oral communication, and presentation skillsintermediate
Required Qualifications
- B.Sc. with 4-5+ years of experience or M.Sc. with 2-3+ years of experience in Biology, Pharmacology, Translational Research, Molecular Biology, or a related discipline (experience)
Preferred Qualifications
- Prior hands-on experience in pre-clinical drug discovery programs (industrial or academic settings) (experience)
- Prior experience working with radioactive materials (experience)
- Experience with in vivo imaging modalities (experience)
- Familiarity with the drug development process and interdisciplinary teamwork (experience)
Responsibilities
- Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents
- Perform essential in vivo procedures: cell culture, tumor cell and PDX fragment implantation, sampling, dosing (IV, SC, IP, PO), tumor and body weight monitoring, and necropsy
- Analyze and interpret experimental data independently; present findings at project team meetings, departmental reviews, and company-wide forums
- Conduct in vitro experiments (e.g., cell viability, cytotoxicity, proliferation, apoptosis, DNA damage response, pathway interrogation) using molecular biology techniques
- Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols
- Support laboratory operations, including inventory management, equipment maintenance, and ensure strict compliance with company policies, GLP, IACUC, and animal welfare guidelines, including accurate documentation in laboratory notebooks and electronic records
- Collaborate effectively within the immediate team and cross-functionally to advance program objectives
- Demonstrate initiative and technical expertise in troubleshooting experimental issues and ensuring accurate data analysis
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
Tags & Categories
Answer 10 quick questions to check your fit for Senior Associate Scientist, Pharmacology @ Bristol-Myers Squibb.
10 Questions
~2 Minutes
Instant Score
Related Books and Jobs