Senior Principal Scientist, ADC Oncology Discovery Biology
Bristol-Myers Squibb
Senior Principal Scientist, ADC Oncology Discovery Biology
Job Description
Experience discovering novel linker-payloads beyond traditional cytotoxic linkers is preferred. Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers is preferred. Bachelor's Degree 10+ years of academic and / or industry experience Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of industry experience 2+ years of leadership experience Experience profiling and developing complex biologics (i.e. bispecifics, biparatopics, masked antibodies) Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes Experience contributing to an IND Experience leading and collaborating across matrixed ADC discovery programs from concept to IND Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity Strong leadership, interpersonal, and communication skills. Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work. Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner. Experience leading, coaching and mentoring a team of lab-based in vitro biologists Excellent oral and written communication skills. Ability to communicate well with peers, supervisors, and governance committees Strong problem-solving skills and understanding of complex scientific principles and demonstrated experience leveraging AI to refine strategic and tactical planning In the role as a Senior Principal Scientist within the ADC Discovery Biology team, the ideal candidate will: Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation. Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates Leverage experience and insights to contribute to the next wave of ADC innovation, including beyond existing payload classes. Collaborate with functional area leads e.g. pharmacology, DMPK, bioinformatics to drive programs forward, including helping to define program priorities and risks. Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships Present complex concepts to a range of audiences including governance and full team project meetings. Utilize excellent communication and interpersonal skills. Communicate via email, meetings, and reports. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Supporting People with Disabilities
About the Role/Company
- The role is within the ADC Discovery Biology team
Key Responsibilities
- Lead highly matrixed ADC discovery teams from target concept to IND
- Lead and mentor a biology team supporting in vitro experimentation
- Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
- Contribute to the next wave of ADC innovation, including beyond existing payload classes
- Collaborate with functional area leads (e.g., pharmacology, DMPK, bioinformatics) to drive programs forward, including helping to define program priorities and risks
- Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
- Present complex concepts to a range of audiences including governance and full team project meetings
- Utilize excellent communication and interpersonal skills
- Communicate via email, meetings, and reports
Required Qualifications
- Bachelor's Degree with 10+ years of academic and/or industry experience
- Ph.D. or equivalent advanced degree in the Life Sciences with 6+ years of industry experience
- + years of leadership experience
- Experience profiling and developing complex biologics (i.e., bispecifics, biparatopics, masked antibodies)
- Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes
- Experience contributing to an Investigational New Drug (IND) application
- Experience leading and collaborating across matrixed ADC discovery programs from concept to IND
- Experienced in the design, development, and optimization of high-throughput cell-based assays for antibody screening and ADC activity
Preferred Qualifications
- Experience discovering novel linker-payloads beyond traditional cytotoxic linkers
- Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers
Skills Required
- Strong leadership, interpersonal, and communication skills
- Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work
- Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner
- Experience leading, coaching, and mentoring a team of lab-based in vitro biologists
- Excellent oral and written communication skills
- Ability to communicate well with peers, supervisors, and governance committees
- Strong problem-solving skills and understanding of complex scientific principles
- Demonstrated experience leveraging AI to refine strategic and tactical planning
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
- Support for people with disabilities
Locations
- Cambridge Crossing MA, United States
Salary
Salary not disclosed
Estimated Salary Rangemedium confidence
200,000 - 350,000 USD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Strong leadership, interpersonal, and communication skillsintermediate
- Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative workintermediate
- Ability to summarize and interpret complex scientific data in a clear, concise, and accurate mannerintermediate
- Experience leading, coaching, and mentoring a team of lab-based in vitro biologistsintermediate
- Excellent oral and written communication skillsintermediate
- Ability to communicate well with peers, supervisors, and governance committeesintermediate
- Strong problem-solving skills and understanding of complex scientific principlesintermediate
- Demonstrated experience leveraging AI to refine strategic and tactical planningintermediate
Required Qualifications
- Bachelor's Degree with 10+ years of academic and/or industry experience (experience)
- Ph.D. or equivalent advanced degree in the Life Sciences with 6+ years of industry experience (experience)
- + years of leadership experience (experience)
- Experience profiling and developing complex biologics (i.e., bispecifics, biparatopics, masked antibodies) (experience)
- Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes (experience)
- Experience contributing to an Investigational New Drug (IND) application (experience)
- Experience leading and collaborating across matrixed ADC discovery programs from concept to IND (experience)
- Experienced in the design, development, and optimization of high-throughput cell-based assays for antibody screening and ADC activity (experience)
Preferred Qualifications
- Experience discovering novel linker-payloads beyond traditional cytotoxic linkers (experience)
- Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers (experience)
Responsibilities
- Lead highly matrixed ADC discovery teams from target concept to IND
- Lead and mentor a biology team supporting in vitro experimentation
- Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
- Contribute to the next wave of ADC innovation, including beyond existing payload classes
- Collaborate with functional area leads (e.g., pharmacology, DMPK, bioinformatics) to drive programs forward, including helping to define program priorities and risks
- Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
- Present complex concepts to a range of audiences including governance and full team project meetings
- Utilize excellent communication and interpersonal skills
- Communicate via email, meetings, and reports
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
- general: Support for people with disabilities
Tags & Categories
Senior Principal Scientist, ADC Oncology Discovery Biology
Bristol-Myers Squibb
Senior Principal Scientist, ADC Oncology Discovery Biology
Job Description
Experience discovering novel linker-payloads beyond traditional cytotoxic linkers is preferred. Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers is preferred. Bachelor's Degree 10+ years of academic and / or industry experience Ph.D. or equivalent advanced degree in the Life Sciences 6+ years of industry experience 2+ years of leadership experience Experience profiling and developing complex biologics (i.e. bispecifics, biparatopics, masked antibodies) Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes Experience contributing to an IND Experience leading and collaborating across matrixed ADC discovery programs from concept to IND Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity Strong leadership, interpersonal, and communication skills. Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work. Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner. Experience leading, coaching and mentoring a team of lab-based in vitro biologists Excellent oral and written communication skills. Ability to communicate well with peers, supervisors, and governance committees Strong problem-solving skills and understanding of complex scientific principles and demonstrated experience leveraging AI to refine strategic and tactical planning In the role as a Senior Principal Scientist within the ADC Discovery Biology team, the ideal candidate will: Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation. Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates Leverage experience and insights to contribute to the next wave of ADC innovation, including beyond existing payload classes. Collaborate with functional area leads e.g. pharmacology, DMPK, bioinformatics to drive programs forward, including helping to define program priorities and risks. Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships Present complex concepts to a range of audiences including governance and full team project meetings. Utilize excellent communication and interpersonal skills. Communicate via email, meetings, and reports. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Supporting People with Disabilities
About the Role/Company
- The role is within the ADC Discovery Biology team
Key Responsibilities
- Lead highly matrixed ADC discovery teams from target concept to IND
- Lead and mentor a biology team supporting in vitro experimentation
- Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
- Contribute to the next wave of ADC innovation, including beyond existing payload classes
- Collaborate with functional area leads (e.g., pharmacology, DMPK, bioinformatics) to drive programs forward, including helping to define program priorities and risks
- Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
- Present complex concepts to a range of audiences including governance and full team project meetings
- Utilize excellent communication and interpersonal skills
- Communicate via email, meetings, and reports
Required Qualifications
- Bachelor's Degree with 10+ years of academic and/or industry experience
- Ph.D. or equivalent advanced degree in the Life Sciences with 6+ years of industry experience
- + years of leadership experience
- Experience profiling and developing complex biologics (i.e., bispecifics, biparatopics, masked antibodies)
- Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes
- Experience contributing to an Investigational New Drug (IND) application
- Experience leading and collaborating across matrixed ADC discovery programs from concept to IND
- Experienced in the design, development, and optimization of high-throughput cell-based assays for antibody screening and ADC activity
Preferred Qualifications
- Experience discovering novel linker-payloads beyond traditional cytotoxic linkers
- Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers
Skills Required
- Strong leadership, interpersonal, and communication skills
- Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work
- Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner
- Experience leading, coaching, and mentoring a team of lab-based in vitro biologists
- Excellent oral and written communication skills
- Ability to communicate well with peers, supervisors, and governance committees
- Strong problem-solving skills and understanding of complex scientific principles
- Demonstrated experience leveraging AI to refine strategic and tactical planning
Benefits & Perks
- Paid national holidays and optional holidays
- Global Shutdown Days between Christmas and New Year's holiday
- Up to 120 hours of paid vacation
- Up to two (2) paid days to volunteer
- Sick time off
- Summer hours flexibility
- Support for people with disabilities
Locations
- Cambridge Crossing MA, United States
Salary
Salary not disclosed
Estimated Salary Rangemedium confidence
200,000 - 350,000 USD / yearly
Source: ai estimated
* This is an estimated range based on market data and may vary based on experience and qualifications.
Skills Required
- Strong leadership, interpersonal, and communication skillsintermediate
- Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative workintermediate
- Ability to summarize and interpret complex scientific data in a clear, concise, and accurate mannerintermediate
- Experience leading, coaching, and mentoring a team of lab-based in vitro biologistsintermediate
- Excellent oral and written communication skillsintermediate
- Ability to communicate well with peers, supervisors, and governance committeesintermediate
- Strong problem-solving skills and understanding of complex scientific principlesintermediate
- Demonstrated experience leveraging AI to refine strategic and tactical planningintermediate
Required Qualifications
- Bachelor's Degree with 10+ years of academic and/or industry experience (experience)
- Ph.D. or equivalent advanced degree in the Life Sciences with 6+ years of industry experience (experience)
- + years of leadership experience (experience)
- Experience profiling and developing complex biologics (i.e., bispecifics, biparatopics, masked antibodies) (experience)
- Experience profiling and developing linker-payloads delivering both cytotoxic and targeted payload classes (experience)
- Experience contributing to an Investigational New Drug (IND) application (experience)
- Experience leading and collaborating across matrixed ADC discovery programs from concept to IND (experience)
- Experienced in the design, development, and optimization of high-throughput cell-based assays for antibody screening and ADC activity (experience)
Preferred Qualifications
- Experience discovering novel linker-payloads beyond traditional cytotoxic linkers (experience)
- Experience with surface antigen target identification and validation and/or design of linker-payloads beyond traditional cytotoxic linkers (experience)
Responsibilities
- Lead highly matrixed ADC discovery teams from target concept to IND
- Lead and mentor a biology team supporting in vitro experimentation
- Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
- Contribute to the next wave of ADC innovation, including beyond existing payload classes
- Collaborate with functional area leads (e.g., pharmacology, DMPK, bioinformatics) to drive programs forward, including helping to define program priorities and risks
- Apply extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
- Present complex concepts to a range of audiences including governance and full team project meetings
- Utilize excellent communication and interpersonal skills
- Communicate via email, meetings, and reports
Benefits
- general: Paid national holidays and optional holidays
- general: Global Shutdown Days between Christmas and New Year's holiday
- general: Up to 120 hours of paid vacation
- general: Up to two (2) paid days to volunteer
- general: Sick time off
- general: Summer hours flexibility
- general: Support for people with disabilities
Tags & Categories