About Gilead Sciences

Gilead Sciences is a leading biopharmaceutical company dedicated to creating a healthier world for all people. For over 35 years, Gilead has pioneered breakthroughs in treating HIV, viral hepatitis, COVID-19, and cancer. The company has delivered a cure for hepatitis C, revolutionary HIV treatments and prevention methods, and advanced therapies for viral, inflammatory diseases, and certain cancers. Headquartered in Foster City, California, Gilead's mission drives relentless innovation to confront the world's biggest health challenges, ensuring access to life-changing therapies globally. With a collaborative culture and bold ambitions, Gilead empowers its teams to make direct impacts on patient lives.

Role Overview

The Sr Clinical Pharmacology Manager position at Gilead Sciences in Foster City, California, is ideal for a PBPK expert passionate about mechanistic physiology-based pharmacokinetic modeling. This role focuses on adapting, developing, and applying PBPK models for small and large molecules, supporting drug-drug interactions, PK predictions for special populations like pregnancy, hepatic/renal impairment, and pediatrics. Applications extend to translational PK, PBPK-PD, and PBPK-QSP, aiding trial design, regulatory submissions, and mechanism of action determinations. As a key contributor to Clinical Pharmacology, you'll drive impactful PK predictions for Gilead's innovative portfolio in HIV, oncology, and inflammatory diseases.

Key Responsibilities

In this senior role, you'll lead the development of sophisticated PBPK models using tools like GastroPlus, Simcyp, and PK-Sim. Responsibilities include crafting minimal and custom PBPK models with R and MATLAB for diverse applications. You'll collaborate with cross-functional teams to refine modeling strategies, present findings to clinical groups, and integrate feedback for optimal outcomes. Expect to provide expert guidance, contribute to regulatory dossiers with reproducible documentation, and maintain meticulous records of data, assumptions, and model evolutions. Proactively identify PBPK opportunities across the portfolio, author manuscripts, present at conferences, and serve as the go-to SME for program-specific queries.

Modeling and Analysis

Core duties involve building models for monoclonal antibodies, bispecifics, ADCs, and more, ensuring predictions support clinical trials and waivers effectively.

Communication and Leadership

Regular interactions with teams and external stakeholders highlight your ability to translate complex models into actionable insights.

Qualifications & Requirements

Basic qualifications include 8+ years of experience with a BS, 6+ years with an MS, 2+ years with a PhD/PharmD, or equivalent. Preferred candidates bring proficiency in mathematical tools like ordinary differential equations, linear algebra, statistics, optimization, and parameter inference. Expertise in PBPK platforms (GastroPlus, Simcyp, PK-Sim preferred) and programming languages such as Python, R, C++, Julia, or MATLAB SimBiology is essential. A basic understanding of molecular biology, drug development, and 3+ years of relevant experience with a PhD/PharmD is highly valued. Experience in QSP, mechanistic PK/PD, or compartmental modeling sets top applicants apart. People leadership skills, including fostering inclusion and talent development, are key accountabilities.

Benefits & Perks

Gilead offers a premium compensation package with estimated salaries ranging from $180,000 to $240,000 annually, reflecting biopharmaceutical sector rates in Foster City with a competitive buffer. Benefits include comprehensive health coverage, generous 401(k) matching, stock options, and wellness programs. Employees enjoy flexible work arrangements, paid parental leave, and tuition assistance for ongoing education. Gilead's commitment to employee well-being extends to mental health resources and onsite fitness facilities, creating a supportive environment for high achievers.

Career Growth

At Gilead, career progression is a priority. As a Sr Clinical Pharmacology Manager, you'll have opportunities to lead projects, mentor juniors, and influence global strategies. The company's investment in development programs, leadership training, and cross-functional exposure accelerates advancement. Many employees transition into director roles or pivot to related areas like regulatory affairs or R&D leadership, fueled by Gilead's growth in HIV, oncology, and inflammatory disease pipelines.

Why Join Gilead

Joining Gilead means contributing to therapies that transform lives, from HIV management to oncology breakthroughs and inflammatory disease solutions. Foster City's state-of-the-art campus fosters innovation in a collaborative, inclusive culture where diverse teams thrive. With a relentless drive for impact, Gilead provides the resources, autonomy, and recognition to fulfill your ambitions. Be part of a company that's cured hepatitis C and continues battling humanity's toughest diseases—your expertise in PBPK modeling will directly support this mission.

Role FAQs

What software experience is required?

Proficiency in GastroPlus, Simcyp, PK-Sim, R, and MATLAB is preferred, with expertise in PBPK modeling essential.

Is leadership experience necessary?

While not mandatory, people leadership accountabilities like creating inclusion and developing talent are emphasized.

What populations does the modeling support?

Special populations including pregnancy, pediatrics, hepatic/renal impairment, plus DDIs and regulatory predictions.

How does this role impact Gilead's pipeline?

Directly supports trial design, submissions, and waivers for HIV, oncology, and inflammatory therapies.

This role offers a unique chance to apply cutting-edge PBPK skills at a world-class biopharma leader. Apply today to help create possible at Gilead Sciences.