Resume and JobRESUME AND JOB
All Profiles
Balvinder Dhaliwal profile photo

Balvinder Dhaliwal

SpainBritish

About

R&D leader with over 25 years' experience across pharma, CDMO and academia. My core expertise is in antibody discovery, protein engineering and structural biology. I lead multidisciplinary teams to progress novel drug candidates from concept through to preclinical development. And regularly present new therapeutic targets and platforms to internal management committees to secure project resources. I am currently on an 18-month secondment to Data Science using AI/ML tools to accelerate biologics discovery and development.

Experience

Principal Scientist & Program Leader

Almirall Ltd. (Pharmaceutical company)

Mar 2021 – PresentBarcelona, Spain

Currently leading drug discovery projects and multidisciplinary teams from target selection to preclinical stage, with an 18-month secondment in Data Science applying AI/ML tools.

  • Conceive novel therapeutic concepts and present them to internal management committees to secure project funding and build a multidisciplinary team.
  • Lead multidisciplinary teams with expertise in disease biology, data science, project management, DMPK/toxicology, in vitro pharmacology, CMC, IP and new product planning, driving projects from target selection to the preclinical stage.
  • Successfully led two biologics discovery projects targeting inflammatory and autoimmune diseases, progressing the projects from target validation through to candidate selection.
  • Identify, evaluate and establish relationships with external CRO, pharma, biotech and academic partners to leverage technologies to strengthen the early drug pipeline.
  • Provide company-wide technical expertise in therapeutic mechanisms of action, biologic discovery and engineering.
  • Currently on an 18-month secondment in Data Science, applying AI/ML tools to accelerate biologic design, humanisation and developability profiling.
  • Serve as a biologics and disease biology subject matter expert on due diligence teams, assessing external assets and acquisition opportunities.

Associate Principal Scientist

Lonza plc. (CDMO)

Jan 2019 – May 2020Slough, UK

Led concurrent client projects, acted as first point of contact for clients, designed and validated assays in a GMP environment, and managed technology transfer.

  • Led concurrent client projects across multiple biologic programmes, meeting all objectives and timelines.
  • Acted as first point of contact for new and prospective clients, building relationships and demonstrating scientific expertise.
  • Designed, developed and validated cell-based, ELISA and SPR assays in a GMP environment for release and stability testing of mAbs, multi-specifics, ADCs and fusion proteins.
  • Wrote, reviewed and critiqued protocols, SOPs and technical reports.
  • Managed technology transfer of assays to manufacturing sites.

Lecturer (Assistant Professor) & Principal Investigator

The University of Manchester

Sep 2014 – Dec 2017Manchester, UK

Led an independent research group, supervised students, designed and delivered lectures, and was an invited speaker.

  • Led an independent research group investigating proteins central to inflammatory and allergic diseases using biological, biophysical and structural techniques.
  • Supervised PhD students, MSc students and undergraduate researchers; all completed their degrees on schedule.
  • Designed and delivered lectures and workshops at undergraduate and master's level; consistently received strong student feedback.
  • Invited speaker at national and international conferences.

Senior Postdoctoral Research Associate

King's College London

Jan 2007 – Dec 2014London

Collaborated with UCB on fragment-based drug design, resulting in a small molecule that entered clinical trials. Led academic projects on biophysical, structural and functional characterisation of novel protein drug targets.

Postdoctoral Research Associate

Baylor College of Medicine

Jan 2006 – Dec 2007USA

Purified and biophysically & structurally characterized DNA transcription factors.

Postdoctoral Research Associate

University of Oxford

Jan 2002 – Dec 2006Oxford

Collaborated with Pfizer and Arrow Therapeutics on anti-viral and anti-bacterial drug candidates; solely responsible for structural and bioinformatics analyses of target protein-small molecule complexes.

Education

PhD in Biochemistry (Structural Biology & Biophysics)

University of Bristol, UK

BSc (Hons) in Biochemistry

University of Sheffield, UK

Grade: 2.1

Skills

Biologics

Biologic Drug Discovery & Development· ExpertmAbs· ExpertMulti-specifics· ExpertNanobodies· ExpertFc-fusions· ExpertDevelopability Profiling· Expert

Drug Discovery

Hit Identification (Biologics)· ExpertTarget Validation· ExpertCandidate Selection· ExpertFragment-based Drug Design· Expert

Drug Development

Preclinical Development· ExpertDMPK· AdvancedToxicology· AdvancedCMC· Advanced

AI/ML

AI/ML-driven Biologic Design· Advanced

AI/ML Tools

AlphaFold· AdvancedBoltz2· AdvancedABodyBuilder2· Advanced

Bioinformatics Tools

Schrödinger BioLuminate· AdvancedBiovia Discovery Studio· Advanced

Structural Biology

Protein Crystallography· Expert

Crystallography Software

CCP4· ExpertPhenix· ExpertBusterTNT· ExpertPyMOL· Expert

Assay Development

Biophysical Characterisation· ExpertFunctional Characterisation· ExpertAssay Development· ExpertAssay Qualification· ExpertAssay Validation· Expert

Assay Techniques

SPR· ExpertITC· ExpertDSF· ExpertFRET· ExpertELISA· ExpertMammalian Cell-based Assays· Expert

Quality Standards

GMP Environments· ExpertNon-GMP Environments· Expert

Management

Team Leadership· ExpertCross-functional Team Leadership· ExpertProject Management· Expert

Scientific Expertise

Disease Biology· ExpertData Science· AdvancedStructural Biology· ExpertBioinformatics· Advanced

Business Development

Due Diligence (Biologics)· ExpertExternal Asset Evaluation· ExpertIntellectual Property (IP)· AdvancedNew Product Planning· Advanced

Pharmacology

In vitro pharmacology· Expert

Languages

English

Expert · Native

Papers & Patents

Author of 19 peer-reviewed papers

Authored 19 peer-reviewed papers relevant to target identification and biologic design.

Inventor on 3 patent applications

Inventor on 3 patent applications in target identification and biologic design.

Additional Roles

Grant reviewer

Grant reviewer for UK research funding bodies.

Expert reviewer

Expert reviewer for several high-impact biochemistry journals.

Fellow of the Higher Education Academy (FHEA)

Fellow of the Higher Education Academy (FHEA).

All Profiles
Balvinder Dhaliwal profile photo

Balvinder Dhaliwal

SpainBritish

About

R&D leader with over 25 years' experience across pharma, CDMO and academia. My core expertise is in antibody discovery, protein engineering and structural biology. I lead multidisciplinary teams to progress novel drug candidates from concept through to preclinical development. And regularly present new therapeutic targets and platforms to internal management committees to secure project resources. I am currently on an 18-month secondment to Data Science using AI/ML tools to accelerate biologics discovery and development.

Experience

Principal Scientist & Program Leader

Almirall Ltd. (Pharmaceutical company)

Mar 2021 – PresentBarcelona, Spain

Currently leading drug discovery projects and multidisciplinary teams from target selection to preclinical stage, with an 18-month secondment in Data Science applying AI/ML tools.

  • Conceive novel therapeutic concepts and present them to internal management committees to secure project funding and build a multidisciplinary team.
  • Lead multidisciplinary teams with expertise in disease biology, data science, project management, DMPK/toxicology, in vitro pharmacology, CMC, IP and new product planning, driving projects from target selection to the preclinical stage.
  • Successfully led two biologics discovery projects targeting inflammatory and autoimmune diseases, progressing the projects from target validation through to candidate selection.
  • Identify, evaluate and establish relationships with external CRO, pharma, biotech and academic partners to leverage technologies to strengthen the early drug pipeline.
  • Provide company-wide technical expertise in therapeutic mechanisms of action, biologic discovery and engineering.
  • Currently on an 18-month secondment in Data Science, applying AI/ML tools to accelerate biologic design, humanisation and developability profiling.
  • Serve as a biologics and disease biology subject matter expert on due diligence teams, assessing external assets and acquisition opportunities.

Associate Principal Scientist

Lonza plc. (CDMO)

Jan 2019 – May 2020Slough, UK

Led concurrent client projects, acted as first point of contact for clients, designed and validated assays in a GMP environment, and managed technology transfer.

  • Led concurrent client projects across multiple biologic programmes, meeting all objectives and timelines.
  • Acted as first point of contact for new and prospective clients, building relationships and demonstrating scientific expertise.
  • Designed, developed and validated cell-based, ELISA and SPR assays in a GMP environment for release and stability testing of mAbs, multi-specifics, ADCs and fusion proteins.
  • Wrote, reviewed and critiqued protocols, SOPs and technical reports.
  • Managed technology transfer of assays to manufacturing sites.

Lecturer (Assistant Professor) & Principal Investigator

The University of Manchester

Sep 2014 – Dec 2017Manchester, UK

Led an independent research group, supervised students, designed and delivered lectures, and was an invited speaker.

  • Led an independent research group investigating proteins central to inflammatory and allergic diseases using biological, biophysical and structural techniques.
  • Supervised PhD students, MSc students and undergraduate researchers; all completed their degrees on schedule.
  • Designed and delivered lectures and workshops at undergraduate and master's level; consistently received strong student feedback.
  • Invited speaker at national and international conferences.

Senior Postdoctoral Research Associate

King's College London

Jan 2007 – Dec 2014London

Collaborated with UCB on fragment-based drug design, resulting in a small molecule that entered clinical trials. Led academic projects on biophysical, structural and functional characterisation of novel protein drug targets.

Postdoctoral Research Associate

Baylor College of Medicine

Jan 2006 – Dec 2007USA

Purified and biophysically & structurally characterized DNA transcription factors.

Postdoctoral Research Associate

University of Oxford

Jan 2002 – Dec 2006Oxford

Collaborated with Pfizer and Arrow Therapeutics on anti-viral and anti-bacterial drug candidates; solely responsible for structural and bioinformatics analyses of target protein-small molecule complexes.

Education

PhD in Biochemistry (Structural Biology & Biophysics)

University of Bristol, UK

BSc (Hons) in Biochemistry

University of Sheffield, UK

Grade: 2.1

Skills

Biologics

Biologic Drug Discovery & Development· ExpertmAbs· ExpertMulti-specifics· ExpertNanobodies· ExpertFc-fusions· ExpertDevelopability Profiling· Expert

Drug Discovery

Hit Identification (Biologics)· ExpertTarget Validation· ExpertCandidate Selection· ExpertFragment-based Drug Design· Expert

Drug Development

Preclinical Development· ExpertDMPK· AdvancedToxicology· AdvancedCMC· Advanced

AI/ML

AI/ML-driven Biologic Design· Advanced

AI/ML Tools

AlphaFold· AdvancedBoltz2· AdvancedABodyBuilder2· Advanced

Bioinformatics Tools

Schrödinger BioLuminate· AdvancedBiovia Discovery Studio· Advanced

Structural Biology

Protein Crystallography· Expert

Crystallography Software

CCP4· ExpertPhenix· ExpertBusterTNT· ExpertPyMOL· Expert

Assay Development

Biophysical Characterisation· ExpertFunctional Characterisation· ExpertAssay Development· ExpertAssay Qualification· ExpertAssay Validation· Expert

Assay Techniques

SPR· ExpertITC· ExpertDSF· ExpertFRET· ExpertELISA· ExpertMammalian Cell-based Assays· Expert

Quality Standards

GMP Environments· ExpertNon-GMP Environments· Expert

Management

Team Leadership· ExpertCross-functional Team Leadership· ExpertProject Management· Expert

Scientific Expertise

Disease Biology· ExpertData Science· AdvancedStructural Biology· ExpertBioinformatics· Advanced

Business Development

Due Diligence (Biologics)· ExpertExternal Asset Evaluation· ExpertIntellectual Property (IP)· AdvancedNew Product Planning· Advanced

Pharmacology

In vitro pharmacology· Expert

Languages

English

Expert · Native

Papers & Patents

Author of 19 peer-reviewed papers

Authored 19 peer-reviewed papers relevant to target identification and biologic design.

Inventor on 3 patent applications

Inventor on 3 patent applications in target identification and biologic design.

Additional Roles

Grant reviewer

Grant reviewer for UK research funding bodies.

Expert reviewer

Expert reviewer for several high-impact biochemistry journals.

Fellow of the Higher Education Academy (FHEA)

Fellow of the Higher Education Academy (FHEA).